NBI’s URICIL
Link between UTI's and Women.
In Australia, about 4 million women, or 1 in 5 women will get an infection of the lower urinary tract at least once at some stage in their life. Recurring UTIs occur in about 50% of this group i.e., about 2 million women or 15% of the total women population in Australia.
The infection of the lower urinary tract system is commonly referred to as infection of the bladder or Cystitis. It is caused by a bacteria called Escherichia coli. (E. coli), which can affect the urethra and bladder and if left untreated, it can lead to more serious conditions affecting the kidney. Let’s first understand our urinary system and infections of the urinary tract.
Urinary System
The urinary system consists of complex structures and processes (organs and cells).
Main Components: The kidney, ureters, urinary bladder, and urethra.Function: Kidneys are responsible for regulating blood volume, pH, and blood pressure. The ureters are responsible for transporting urine from the kidney to the bladder. The bladder stores urine and expels it into the urethra and the urethra discharges urine from our body.
(Tortora et al., 2019)
Tortora, G. J., Mellifont, R., Derrickson, B., Burkett, B., Peoples, G., D, D. (2019). Principles of anatomy and physiology 2nd Asia-Pacific edition, 2nd Edition. [[VitalSource Bookshelf version]]. Retrieved from vbk://9780730354987
Infection of the Urinary Tract
This is largely caused by bacteria and in most cases by uropathogenic bacteria E. coli (UPEC). This is a common pathogenic bacteria found in our lower gut. Pathogenic bacteria can find their way into our urinary tract through the penis in males and vagina in females and where it can travel up the urethra and into our bladder where they form colonies. The pain is largely caused by the inflammation of the bladder induced by the bacteria.
UTIs happens more frequently in females than males due to the length of the urethra. Females have a shorter urethra than males and the opening of the urethra is closer to the anus and the vagina. Bacteria can be accidentally introduced to the urethra by wiping fecal matter post bowel movement. The bacteria travels up the urethra and reside in the bladder where urine in the bladder provides a good environment for bacteria to multiply and form colonies. Learn the link between E.coli and UTIs.
Uricil: Self-medication for the treatment of non-complicated UTI
Uricil is a patented product comprising of a Urinary alkaliser and antibacterial agent for the treatment of non-complicated urinary tract infections (UTIs) and provides symptomatic relief. Learn more about Natural Over the Counter for UTIs here.
Active ingredients linked to this claim:
Each capsule contains: UC3 Clear (Curcuma longa): 27.25mg
Equivalent to Curcuminoids: 2.53mg
Potassium Citrate: 753.95mg
Equivalent to Potassium: 272.60mg
Dosage: *6-12 years one capsule/day. 13 years and above 2 capsules, 2 times/day *Dosage may be varied by health professionals
Suitable for: This product is formulated for children and adults, with medically diagnosed cystitis. Curcumin (diferuloylmethane) is a compound naturally present in turmeric. It is extracted, purified, and hydrolysed to increase its bioavailability.
NBI's Uricil is a patented product.
Contraindication: Contains potassium. If you are on any other medications or health conditions, please talk to your healthcare provider.
Evidence Summary
Results from an invitro studies conducted by Neptune Bio-Innovations in collaboration with Merieux NutriSciences Laboratory, Australia suggested that ANTIBACTERIAL EVALUATION OF UC-IC50-2 (hydrolysed diferuloylmethane) (BS EN 1276:2009 (Modified)) at 37°C
Results: With a minimal dose of 10 mg, Uricil achieved log 5 reductions against test organism Escherichia coli ATCC 25922 (Antibiotic-Resistant Strain) with a 99% kill rate.
There are large body of evidence indication curcumin as a potent anti-inflammatory, antioxidant, and a bactericidal.
Curcuminoids vs Antibiotics
In 2019, Rangel-Castañeda Itzia Azucena et.al.6 showed a combinatorial benefit when curcumin was used in conjunction with antibiotics. Maximum synergy was observed with combinations of 330 μg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Therefore, this study demonstrated patients with recurring UTIs could benefit with Uricil. In another prospective study by Arunava Kali et. al., 20197 a combination of antibiotics and curcumin has a significant antibacterial action against biofilm-producing bacterial isolates.
NBI’s Uricil natural OTC for UTIs
NBI’s Uricil is a Urinary Tract Infection (UTI) over-the-counter medicine for cystitis, kills the uropathogenic bacteria that cause UTIs and provides relief from scalding pain. URICIL is a 2-in-1 urinary alkalizer and natural antibacterial that can help treat your UTIs effectively with a natural potent antibacterial agent that can be used in therapeutic prophylactic and symptomatic relief from UTIs, and is suitable for recurrent UTIs.
Shop our powerful formula URICIL online at www.nepbio.com
Try the medication yourself to see its effectiveness.